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Gram-negative Eradication Program

Gram-negative Eradication Program

Gram-negative rods (GNRs) are becoming more prevalent in hospitals worldwide. They are increasingly resistant to antibiotics and are associated with poor clinical outcomes. Their prevention has become a key priority for many hospitals due to increased length of patient stay and increased associated costs.

Effective environmental contamination control is essential in controlling the spread of GNRs. Bioquell provides a rapid and effective bio-decontamination solution to limit the spread of a GNR outbreak, and can work closely with hospitals to proactively prevent the occurrence of GNRs in the hospital environment.

> Explore our Acinetobacter baumannii microbiology area.
 

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Features

Whether a hospital is experiencing an outbreak or endemic GNR issues, Bioquell's Gram-negative Eradication Program will maximize the benefits from Bioquell's technology, while minimizing the operational challenges to the hospital.

Each program can be tailored to meet your hospital's specific needs.

Benefits

  • Bioquell is the only HPV technology which is able to overcome catalase-positive micro-organisms and can totally eradicate Gram-negative pathogens from the environment. It is verified by inactivation of 6-log Geobacillus stearothermophilus biological indicators, the same method used to validate steam sterilizers/autoclaves 
     
  • Bioquell offers a tailor-made service with the ability to eliminate GNRs from single rooms in less than 2 hours*. This is far quicker than stringent cleaning protocols allowing for faster room turnaround
     
  • Entire unit bio-decontamination can be carried out in less than 12 hours and has the added benefit of decontaminating common areas (e.g. nursing stations)
     
  • By reducing cleaning downtime and preventing bed-blocking by patients infected with GNRs, Bioquell's Gram-negative eradication program can increase the number of patients treated per year, generating significant cost benefits
     
  • Full reporting, designed to assist the hospitals management and support regulatory requirements
     
  • Extensive worldwide experience, with over 100 successful Bioquell Outbreak Emergency deployments
     

* depending on room size and starting environmental conditions

FAQs

 
What evidence is there that Bioquell can suppress the spread of Gram-negatives?

Bioquell has been used to control several outbreaks of Gram-negatives around the world. Many of these remain unpublished but several have been published, for example, an outbreak of Acinetobacter and Enterobacter on an ICU in the Netherlands (Otter JA, Yezli S, Schouten MA, van Zanten AR, Houmes-Zielman G, Nohlmans-Paulssen MK. Hydrogen peroxide vapor decontamination of an intensive care unit to remove environmental reservoirs of multidrug-resistant gram-negative rods during an outbreak. Am J Infect Control 2010; 38: 754-756); an outbreak of Serratia marcescens on a neonatal ICU in Sheffield (Bates CJ, Pearse R. Use of hydrogen peroxide vapour for environmental control during a Serratia outbreak in a neonatal intensive care unit. J Hosp Infect 2005; 61: 364-366.); and an outbreak of A. baumannii in an ICU in the USA (Donnegan N, Croxton M, Jones M, Farrare-Wilmore P, Geiser K, Pic-Aluas L. Vaporized Hydrogen Peroxide as Part of a Control Intervention during an Outbreak of Acinetobacter in an ICU. Society for Healthcare Epidemiologists of America Annual Meeting, 2010, Abstract 207). The control of multidrug-resistant Gram-negatives is crucially important in light of the emergence and spread of carbapenemases such as NDM-1 and KPC-2.

What evidence is there that Bioquell can reduce endemic rates?

The hospital-wide introduction of Bioquell HPV was associated with a reduction in the incidence of C. difficile infection in a study published in 2008 from a US hospital (Boyce JM, Havill NL, Otter JA et al. Impact of hydrogen peroxide vapor room decontamination on Clostridium difficile environmental contamination and transmission in a healthcare setting. Infect Control Hosp Epidemiol 2008; 29: 723-729). Two papers presented at conferences since then by US hospitals report significant reductions in C. difficile and the risk of VRE acquisition (Passaretti CL, Otter JA, Lipsett P et al., Adherence to Hydrogen Peroxide Vapor (HPV) decontamination reduces VRE acquisition in high-risk units. 48 th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) and the Infectious Diseases Society of America (IDSA). Washington DC, USA, 2008. Abstract K4124b; Manian FA, Griesenauer S, Senkel D. Impact of an intensive terminal cleaning and disinfection (C/D) protocol involving selected hospital rooms on endemic nosocomial infection (NI) rates of common pathogens at a tertiary care medical center. 5th Decennial Meeting of the Society for Healthcare Epidemiology of America (SHEA), Atlanta, GA, USA. Abstract LB6). A recent letter from a UK hospital reported that a reduction in the incidence of C. difficile was associated with the implementation of Bioquell HPV (Cooper T, O’Leary M, Yezli S, Otter JA. The impact of environmental decontamination using hydrogen peroxide vapor on the incidence of Clostridium difficile infection in one hospital trust. J Hosp Infect accepted). Other research investigating the impact of Bioquell on endemic rates of infection is ongoing.

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